| Chemical Name | CALLERY? Sodium hexamethyldisilazane, 40% solution in tetrahydrofuran |
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| Synonym |
HEXAM
HMN NA SALT
HMN-Na 溶液 六甲基二硅氮烷 鈉鹽 溶液
N-SODIUMHEXAMETHYLDISILAZANE
N-Sodiohe
N-Sodiohexamethyldisilazane
N-Sodiumhexamethyldisilazane
N-lithiohexamethyldisilazane
NAHMDS
Natrium-bis-(trimethylsilyl)-amid
Natriumbis-(t
SOD
SODIU
SODIUM BIS(TRIMETHYLSILYL)AMIDE SOL., ~0 .6 M IN TOLUENE
SODIUM BIS(TRIMETHYLSILYL)AMIDE, ~1 M IN THF
Sodium bis(trimethylsilyl)amide
Sodium bis(trimethylsilyl)amide, pure, 95+%
Sodium hexamethyldisilazane
hex
hexamethyldisilazane
hexamethylsilazane
hexamethylsilazane, aluminum salt
hexamethylsilazane, beryllium salt
hexamethylsilazane, cadmium salt
hexamethylsilazane, cerium (+3) salt
hexamethylsilazane, chromium (3+) salt |
| MDL Number | MFCD00009835 |
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| CAS Number | 1070-89-9 |
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| EC Number | 213-983-8 |
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| Beilstein Registry Number | 3629917 |
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| PubChem Substance ID | 2724254 |
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| Reaxys-RN | 3629917 |
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| Chemical Name Translation | 雙(三甲基硅基)氨基鈉 |
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| InChIKey | WRIKHQLVHPKCJU-UHFFFAOYSA-N |
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| InChI | InChI=1S/C6H18NSi2.Na/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1 |
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| Signal word |
Danger |
GHS Symbol
| WGK Germany | 3 |
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| Safety Statements | |
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- S16 Keep away from sources of ignition - No smoking 遠離火源，禁止吸煙；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接觸后，立即用大量水沖洗并征求醫生意見；
- S33 Take precautionary measures against static discharges 對靜電采取預防措施；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴適當的防護服、手套和眼睛/面保護；
- S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 著火時使用（指明具體的消防器材種類，如果用水增加危險，注明“禁止用水”
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 發生事故時或感覺不適時，立即求醫（可能時出示標簽）；
- S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求醫并出示該容器或標簽；
- S8 Keep container dry 保持容器干燥；
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| Risk Statements | |
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- R11 Highly flammable 非常易燃
- R14 Reacts violently with water 遇水會猛烈反應
- R14/15 Reacts violently with water, liberating extremely flammable gases 遇水劇烈反應，釋放出高度可燃氣體
- R19 May form explosive peroxides 可能生成易爆的過氧化物質
- R34 Causes burns 會導致灼傷
- R37 Irritating to respiratory system 刺激呼吸道
- R40 Limited evidence of a carcinogenic effect 有限證據表明其致癌作用
- R48/20
- R63 Possible risk of harm to the unborn child 可能危害未出生嬰兒
- R65 Harmful: may cause lung damage if swallowed 若吞咽可能傷害肺部器官
- R67 Vapours may cause drowsiness and dizziness 蒸汽可能導致嗜睡和昏厥
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| Precautionary statements | |
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- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 遠離熱源/火花/明火/熱的表面?！刮鼰?。
- P233 Keep container tightly closed. ?保持容器密閉。
- P240 Ground/bond container and receiving equipment. 與地面接觸/連接集裝箱和接受設備。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆電氣/通風/照明/ .../設備。
- P241+P242+P243
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉塵/煙/氣體/煙霧/蒸汽/噴霧。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉塵/煙/氣體/煙霧/蒸汽/噴霧。
- P264 Wash hands thoroughly after handling. 處理后要徹底洗凈雙手。
- P264+P265
- P270 Do not eat, drink or smoke when using this product. 使用本產品時不要吃東西，喝水或吸煙。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通風良好的地方使用。
- P273 Avoid release to the environment. 避免釋放到環境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防護手套/防護服/眼睛的保護物/面部保護物。
- P301+P312
- P301+P317
- P301+P330+P331
- P301+P330+P331+P310
- P302+P352
- P302+P361+P354
- P303+P361+P353
- P303+P361+P353+P310+P363
- P304+P312
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P305+P354+P338
- P308+P311
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或醫生/醫師。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感覺不適，呼叫解毒中心或醫生/醫師。
- P316
- P317
- P321 Specific treatment (see … on this label). 具體治療（見本標簽上的）。
- P322 Specific measures (see …on this label). 具體治療（見本標簽上的）。
- P330 Rinse mouth. 漱口
- P362+P364
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗凈后方可重新使用。
- P403+P233
- P405 Store locked up. 上鎖保管。
- P501 Dispose of contents/container to..… 處理內容物/容器.....
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| Hazard statements | |
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- H225 Highly flammable liquid and vapour 高度易燃液體和蒸氣
- H302 Harmful if swallowed 吞食有害
- H304 May be fatal if swallowed and enters airways 吞食和進入呼吸道可能致命
- H312 Harmful in contact with skin 皮膚接觸有害
- H314 Causes severe skin burns and eye damage 導致嚴重的皮膚灼傷和眼睛損傷
- H318 Causes serious eye damage 嚴重傷害眼睛
- H332 Harmful if inhaled 吸入有害
- H335 May cause respiratory irritation 可能導致呼吸道刺激
- H336 May cause drowsiness or dizziness 肯能導致嗜睡或頭暈
- H351 Suspected of causing cancer 懷疑致癌
- H361d Suspected of damaging the unborn child 懷疑對未出生嬰兒造成傷害
- H373 May causes damage to organs through prolonged or repeated exposure 長期或頻繁接觸可能會損傷器官
- H412 Harmfutoaquaticlifewithlonglastingeffects 對水生生物有害并具有長期影響。
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| Personal Protective Equipment |
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
| Packing Group | II |
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| UN Number |
2924
UN2924
UN3096 |
| Storage condition |
Moisture Sensitive
易吸潮，密封保存。充入惰性氣體，密閉保存。
Air & Moisture Sensitive
充氬保存
2-8°C |
| Hazard Codes |
3
F,C |
| Hazard Class | 3/8 |
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⑴. 常溫下為微黃色至淺灰色結晶粉末，一般溶于四氫呋喃溶液中。
⑵. 與銠(I)催化共同作用可顯著加快苯乙炔的聚合反應。
⑶.又稱雙(三甲基癸基)氨化鈉
Significantly accelerated the polymerization of pheneylacetylene in conjunction with rhodium (I) catalysis
{ALF} Sufficiently nucleophilic to act as a protected form of ammonia in the synthesis of primary amines from halides and tosylates: Chem. Ber., 117, 1250 (1984).
{ALF} Useful sterically hindered base (NaHMDS) for, e.g. generation of enolates, Wittig reagents or carbenes.
{ALF} In the Wittig reaction, gives Li salt-free product distribution patterns, with selective (Z)-alkene formation: Chem. Ber., 109, 1694 (1976); Tetrahedron Lett., 30, 2173 (1989). For formation of anions of benzylic phosphonates and subsequent ɑɑ-difluorination, see N-Fluorobenzenesulfonimide, L13955.
{ALF} Used as a base for the preparation of ester enolates: J. Am. Chem. Soc., 93, 4945 (1971). Has been found to be superior to LDA for preparation of (Z)-enolates of ketones under thermodynamic control: Tetrahedron Lett., 30, 2779 (1989).
{uni_hamburg} Short: EINECS
{ALD} Beilstein: 4,IV,4014
{uni_hamburg} Short: III/35F
{ALF} Found to give better yields than LiHMDS or KHMDS for the carbenoid reactions with Dibromomethane, A10456: Synthesis, 201 (1972); Angew. Chem. Int. Ed., 11, 326 (1972).
